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Stem cell culturet
supernatan treatment

(High concentration exosome therapy)

Growth factors (cytokines) and exosomes promote the activation of weakened cells, repairing and regenerating damaged tissues and cells, bringing revolutionary effects in disease treatment, health maintenance, and beauty.

What’s the PRPGH

What’s the PRPGH

Do you know that our human body is made up of 60 trillion cells in order to maintain our body?
All tissues in the body, such as blood, bones, skin and organs, are made up of cells. Cells are depleted and discarded day by day, new cells are born, constantly being reborn in the body.
All cells are not the same, and there are various types of cells depending on the body’s tissues and organs, and each cell plays a specific role.
This regeneration is supported by cells called “stem cells,” which constantly replenish new cells by dividing and differentiating.
Stem cells have two major characteristics: self-renewal ability and differentiation ability. “Self-renewal ability” is the ability to repeat division and increase proliferation with the same shape and ability as yourself.
In a word, self-renewal allows the exact same stem cells to proliferate.

On the other hand, “differentiation ability” refers to the ability to create various cells necessary for building the body and has the ability to change into several different types of tissue cells such as vascular endothelial cells, nerve cells, and bone cells.
The application of these characteristics of stem cells is attracting attention as “regenerative medicine.

What’s the Stem cell

What’s the Stem cell

Stem cell culture supernatant is a supernatant solution made by extracting stem cells from the culture medium used for culturing stem cells, centrifuging the remaining culture medium, and subjecting it to sterilization.
Stem cells are cultured, activated during the process of proliferation, and release hundreds of humoral factors (growth factors, exosomes, etc.) into the culture medium.
Growth factors (cytokines) and exosomes promote the activation of weakened cells, repairing and regenerating damaged tissues and cells, bringing revolutionary effects in disease treatment, health maintenance, and beauty.
Adult stem cells include umbilical cord, bone marrow, dental pulp, and adipose-derived stem cells.
Among them, adipose-derived stem cells can be safely and easily collected in large quantities.
At our clinic, we use the stem cell culture supernatant to treat thinning hair by injecting it into the scalp or by Intravenous drip.

What are exosomes?


You often see the word “exosome” in beauty clinics and social media these days. Stem cell culture supernatant contains growth factors and “exosomes,” and exosomes are capsule-shaped substances that are one of the components secreted from human cells.
They gather in injured cells and promote the activation of cells in the damaged area.
Although it is quite small, one millionth of a millimeter in size, there is a lot of information packed into that tiny capsule.
Exosomes secreted from cells are also present in body fluids (blood, spinal fluid, urine, etc.) and are said to play a role in transmitting information between cells.
In other words, exosomes can be said to be cellular messengers.
It travels throughout the body and transmits necessary information when something abnormal occurs, reinforcing damaged cells and their surroundings and encouraging the cells to recover on their own.

This action promotes the repair and regeneration of hair matrix cells, cell differentiation and proliferation, improves the scalp environment, and promotes hair growth.
This ability to deliver ingredients that promote hair regeneration to the hair roots, differentiate and proliferate hair follicle cells, and repair damaged hair follicles is also attracting attention in the field of hair loss treatment.
It is said to be effective for hair thinning symptoms such as AGA and FAGA, but it is not suitable for treating alopecia areata.
In addition, it is also said to be effective in improving skin spots, dullness, and pores, but it will not turn gray hair black.

Difference between stem cell culture supernatant therapy and exosome therapy

Stem cell culture supernatant therapy and exosome therapy are completely different things, and their actions and roles are also very different!


Stem cell culture supernatant contains exosomes, but not only exosomes.
In addition to exosomes, they also contain components such as cytokines (growth factors), hormones, extracellular matrix, and RNA.
This highly purified substance extracted from only cytokines and active ingredients is called “stem cell culture supernatant,” but it actually contains only a small amount of exosomes.
These growth factors and active ingredients promote the activation of weakened cells, repair and regenerate damaged tissues and cells, and can be expected to have hair growth and hair growth effects.

Scalp injection 1 time(1 vial 88,000yen
3 time(1 vial) 211,200yen
5 time(1 vial) 308,000yen
Face injection 1 time(1 vial) 99,000yen
3 time(1 vial) 237,600yen
5 time(1 vial) 346,500yen
Intravenous drip 1time(1 vial) 33,000yen
(2 vial) 56,100yen
Anesthetization 3,000yen

By injecting a stem cell culture supernatant containing a high proportion of exosomes into the head,it is expected to promote the repair and regeneration of hair matrix cells, cell differentiation and proliferation, and promote hair growth. The stem cell culture supernatant we handle at our clinic has a higher exosome ratio, so it contains more and more exosomes.

Scalp injection 1 time(1 vial) 154,000yen
3 time(1 vial) 446,000yen
5 time(1 vial) 693,000yen
Face injection 1 time(1 vial 165,000yen
3 time(1 vial) 470,000yen
5 time(1 vial) 742,000yen
Intravenous drip 1time(1 vial) 99,000yen
(2 vial) 178,100yen

Functions of major growth factors (cytokines)

bFGF (Basic Fibroblast Growth Factor) Gives signs of epidermal cell production to epidermal stem cells and promotes skin turnover (metabolism). It can be expected to improve stains and dullness.
aFGF(Acidic Fibroblast Growth Factor) Stimulates and proliferates dermal stem cells (fibroblasts).
It can be expected to have hair growth, hair growth promotion, anti-aging, wrinkle improvement, and whitening effects.
KGF(Keratinocyte Growth Factor) It works on hair matrix stem cells to promote hair growth.
By activating hair matrix cells during the hair growth period, hair growth and hair restoration effects can be expected.
VEGF(Vascular Endothelial Growth Factor) It plays an important role in angiogenesis (branching and extending from existing blood vessels to form blood vessels).
A hair growth effect can be expected due to the new formation of capillaries.
TGF-β(Transforming Growth Factor -β) It has an anti-inflammatory effect, etc., and promotes proliferation and new generation of epithelial cells and vascular endothelium.
In addition, since it promotes collagen production and strengthens the action of elastin, it can be expected to improve sensitive skin.
IGF-1(Insulin-like Growth Factor-1) By regenerating new skin cells and promoting the production of collagen, elastin, and hyaluronic acid, it regenerates the firmness and elasticity of the skin.
In the hair cycle of hair, it can be expected to have a hair growth effect because it extends the period of the growth period and also affects the shortening of the regression period and the resting period.
PDGF(Platelet-Derived Growth Factor) It stimulates stem cells involved in tissue repair, such as fibroblasts, adipose stem cells, and epithelial stem cells, and promotes division.
Hair growth and hair restoration effects can be expected due to cell growth promotion, angiogenesis, and macrophage activation.
HGF(Hepatocyte Growth Factor) HGF is a hepatocyte growth factor, and it works to improve the function of the liver.
It is involved not only in the liver, but also in regeneration of tissues such as promotion of cell proliferation of skin cells, promotion of cell movement, induction of morphogenesis, and angiogenesis.

Symptoms targeted for this treatment

Hair loss or thinning hair
Alopecia areata
Aging care
Maintain good health
Recover from physical ailments

There is also an effect of improvement of disease, health maintenance, and beauty effect!

Illness improvement and health maintenance
  • Angiogenesis/angiogenic action (improvement and prevention of progression of arteriosclerotic lesions, ED treatment, etc.)
  • Improvement of pain (joint pain, stiff shoulders, frozen shoulders, etc.)
  • Immunomodulating action (allergic diseases, autoimmune diseases)
  • Nerve cell repair/regeneration (cerebral infarction/spinal cord injury)
  • Bone regeneration (osteoporosis, gingivitis)
  • Scavenger (active oxygen removal) action (recovery from fatigue, prevention of lifestyle-related diseases, etc.)
  • Stem cell differentiation promoting action in the body (induction of self-renewal ability, etc.)
  • Tissue repair (liver damage, interstitial pneumonia, etc.)
  • Metabolism improvement (diabetes, etc.)
Beauty effect
  • Improvement of thinning hair (AGA/FAGA) and hair growth effect
  • Improvement of skin wrinkles and sagging
  • Whitening and improvement of dark circles under the eyes
  • Promote wound healing (scars)
  • Body anti-aging
  • Improvement of atopic dermatitis

In Osaka AGA Kato Clinic namba, we use stem cell culture supernatant as a treatment for thinning hair.
Inject directly into the area of concern on the head in order to fully demonstrate the hair growth effect.
Also, if you do an infusion, you can not only grow hair, but also have anti-aging and beauty effects on your whole body, so you can solve your skin problems together!

Treatment flow

Scalp injection

01Consultation with staff and doctor

After about 10 minutes of counseling by the staff, the doctor will check the scalp, and explain the stem cell culture supernatant treatment.

02Inject the stem cell

Doctor injects the stem cell into the scalp of the thinning hair part, it takes about 5 to 10 minutes.
Some bleeding will occur during the procedure.
There are individual differences in the amount of bleeding, but most people stop bleeding immediately.

Intravenous drip

01Consultation with staff and doctor

After about 10 minutes of counseling by the staff, the doctor will check the scalp, and explain the stem cell culture supernatant treatment.

02Intravenous drip

It takes about 20 to 30 minutes, depending on the vial used, as it will be dripped into the vein slowly over time.
We recommend that you have enough time to receive the treatment.


  • After injection, redness and swelling may occur at the injection site.
  • If you receive stem cell culture supernatant treatment, you cannot donate blood.
  • Please refrain from washing your hair on the day of the procedure.
  • Please refrain from strenuous exercise, sauna, bedrock bathing, bathing, etc. on the day of treatment.
  • Please refrain from hair coloring, perming and scalp massage for 1 week before and after treatment.
  • Avoid intense sun exposure before and after treatment.
  • In rare cases, it can cause allergies.
  • There are individual differences in the therapeutic effect.
  • Since there are individual differences in the growth of cells around the hair root, it may be difficult to see the effect.

Unapplicable case

  • Persons undergoing cancer treatment or those who have recently undergone cancer treatment
  • Pregnant, may become pregnant, or are breastfeeding
  • Persons with severe allergies
How soon can you feel the effects?
The effect varies from person to person depending on the symptoms and the purpose of treatment, but if you are early, you can feel the effect in about 2 to 3 weeks.
Will there be pain during the injection?
In the case of scalp injection, a block anesthesia is given.
There is pain during anesthesia, but there is no pain during injection.
The drip is slightly painful only when the needle is inserted.
Are there any side effects?
Redness and swelling may occur at the injection site, but no major side effects have been reported so far.
However, for those with severe allergies, we recommend performing an intradermal test before treatment.
Is one treatment enough?
We think that you can feel the effect, but it is recommended that you receive the treatment on a regular basis in order to demonstrate a higher effect by performing the treatment continuously.
Is there anything I should be aware of in my daily life after the treatment?
There are no particular restrictions, but we recommend that you rest quietly on the day of the treatment.
How often is it effective?
Although it depends on the desired therapeutic effect, we recommend that you perform the treatment once every 4 weeks.